She later became known for her leading role in television drama Reply 1988 (2015), which was the highest-rated drama in Korean cable television history at the time. She ranked third in Forbes Korea Power Celebrity list in 2016, and is one of the highest-paid commercial models in South Korea.
She was a regular cast member on Amazing Saturday (2018-2020).
In September 2010, Hyeri was announced as a new member of Girl`s Day alongside Yura when Jiin and Jisun left the group, just two months after the group debuted.
The revamped group released a single titled Nothing Lasts Forever, and went on to become one of the most popular and commercially successful musical quartets of its era.
In January 2014, Hyeri fainted on stage during a Girl`s Day live performance and had to be carried off-stage by M Countdown staff. She was later diagnosed with swine flu.
After her exclusive contract with Dream T Entertainment ended in 2019, Hyeri joined a newly set-up agency Creative Group ING.
Although all four members joined separate agencies, they have stated that the group has not disbanded.
In 2012, Hyeri made her acting debut in the SBS weekend drama Tasty Life, where she played the youngest in a family of four daughters.
After her 4-day long appearance on Real Men in August 2014, a brief clip of her showing aegyo at her instructor went viral in South Korea, reaching one million views in a day, an unprecedented feat at the time.
She consequently shot to stardom overnight, and later won Best Female Newcomer award at the MBC Entertainment Awards for her Real Men appearance.
In November 2014, Hyeri was cast as one of the main characters in teen drama Schoolgirl Detectives, which began airing on cable channel jTBC in December.
In late 2014, she was also cast in the mystery rom-com drama Hyde, Jekyll, Me, which began airing on SBS in January 2015.
In 2015, Hyeri was cast as the lead of the tvN drama Reply 1988.
The drama premiered in November and went on to become a commercial success with audience ratings peaking at 18.8%, making it one of the highest rated dramas in Korean cable television history.
Hyeri received critical and audience acclaim for her award-winning portrayal of the female protagonist.
In 2016, Hyeri was cast as the lead in the SBS drama Entertainer along with actor Ji Sung and CNBLUE member Kang Min-hyuk, which began airing on April 20 and for which she won New Star Award at 2016 SBS Drama Awards.
In 2017, she also starred in the police comedy drama Two Cops alongside Jo Jung-suk and Kim Seon-ho.
In 2017, it was announced that Hyeri would be making her big screen debut as the female lead in Monstrum; filming began in April.
Monstrum premiered in September, 2018. In 2018, Hyeri was cast in My Punch-Drunk Boxer, a boxing comedy drama film.
The film premiered at 20th Jeonju International Film Festival in September, 2019; its general release followed in October, 2019.
In 2019, Hyeri also starred in tvN`s office comedy drama Miss Lee.
Besides acting, Hyeri frequently guests on variety shows. She has been described as a blue chip in the entertainment industry due to her frank and easy-going charms, bright energy and flexible chemistry with other cast members.
Since 2018, Hyeri had been a regular cast member of DoReMi Market, a weekly television program airing on tvN.
In late 2020, she left the show to focus on her acting career.